Biomaterial Database

Measurements of airway edema in allergic bronchoconstriction in the guinea pig. 1981

E Jeffries, and P D Pare, and J C Hogg

We tested the hypothesis that acute bronchoconstriction in the guinea pig was associated with airway edema by measuring extravascular water in the airways and lung parenchyma. Thirty guinea pigs were immunized with egg albumin and 30 nonimmunized guinea pigs served as controls. An aerosolized challenge with egg albumin produced acute respiratory distress in the immunized but not in the control animals. The animals were killed (6 per group) immediately and 1, 3, 6, and 24 h after the challenge, and the extravascular water content of the airways and parenchyma was measured. We found that airway extravascular water varied from 3.90 +/- 0.58 to 3.12 +/- 0.25 g/g dry tissue in the control group and from 3.61 +/- 0.41 to 3.79 +/- 0.33 g/g dry tissue in the experimental group. A two-way analysis of variance showed no difference between the groups. Similar results were found in parenchymal samples. We concluded that allergic bronchoconstriction in the guinea pig is not associated with airway edema.

UI	MeSH Term	Description	Entries
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D001980	Bronchi	The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.	Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D001982	Bronchial Diseases	Diseases involving the BRONCHI.	Bronchial Disease,Disease, Bronchial,Diseases, Bronchial
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000402	Airway Obstruction	Any hindrance to the passage of air into and out of the lungs.	Choking,Airway Obstructions,Obstruction, Airway,Obstructions, Airway
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas