-transparent.png){kind=logo}
The present study was designed to determine whether endogenous and exogenous adenosine modulates endothelin (ET)-induced bronchoconstriction. Exogenous adenosine enhances ET-induced bronchoconstriction. Following pretreatment with adenosine deaminase and theophylline to eliminate or antagonize endogenous adenosine, ET-1-induced bronchoconstriction was significantly attenuated, but not that of ET-3. In conclusion, this is the first report of an enhancement of ET-induced bronchoconstriction of guinea pig airways by endogenous and exogenous adenosine. Our findings may be useful in designing specific adenosine receptor antagonists as therapeutic agents in the management of bronchial asthma.
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
June 1992,
Regulatory peptides,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
February 1996,
Journal of applied physiology (Bethesda, Md. : 1985),
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
August 1989,
The Journal of pharmacology and experimental therapeutics,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
August 1996,
American journal of respiratory and critical care medicine,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
September 2002,
European journal of pharmacology,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
January 1988,
Pulmonary pharmacology,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
January 1996,
Acta physiologica Hungarica,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
January 1969,
The Journal of physiology,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
June 1981,
The American review of respiratory disease,
H Kanazawa, and
H Fujiwara, and
S Shoji, and
T Fujii, and
S Kudoh, and
K Hirata, and
N Kurihara, and
J Yoshikawa
June 1991,
Journal of pharmacobio-dynamics,
