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The contribution of cytoplasm in the suppression of tumorigenicity was examined in cybrids constructed by fusing whole tumorigenic mouse mammary cells (Balb/c, cell line C2B2 from line MT29240) with enucleated nontumorigenic cells (BALB/c, cell line THOC from clone A31). Chloramphenicol resistance was used as a cytoplasmic marker in selecting the cybrids. Hybrids from parental nonenucleated cells were also isolated and analyzed for the expression of tumorigenicity. A reduction of the tumorigenic capacity in terms of tumor incidence and latency was clearly expressed in most of the cybrid clones studied. In the cybrids, saturation density and colony formation in agarose was also reduced. In most of the hybrid clones studied, a reduction was also observed in the tumorigenic capacity but not in saturation density or anchorage independence.
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December 1980,
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L Giguère, and
R Morais
July 1978,
Somatic cell genetics,
L Giguère, and
R Morais
February 1988,
Cancer research,
L Giguère, and
R Morais
January 1981,
Experimental cell biology,
L Giguère, and
R Morais
October 1978,
Pathology,
L Giguère, and
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January 1993,
In vivo (Athens, Greece),
L Giguère, and
R Morais
January 1975,
Proceedings of the National Academy of Sciences of the United States of America,
L Giguère, and
R Morais
May 1984,
Somatic cell and molecular genetics,
L Giguère, and
R Morais
August 1982,
Gan,
L Giguère, and
R Morais
January 1982,
Cytogenetics and cell genetics,
