-transparent.png){kind=logo}
Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabain resistance. No mutants above background were induced by exposure to BUdR in G1 and G2 cells, and very few mutants were induced in the latter part of the DNA synthesis period. The peak for the induction of 6TG resistance occurs at about two hr in the DNA synthesis period; one hour later there is a peak for the induction of ouabain resistance. Both peaks occur before the time of maximum incorporation of BUdR into DNA. These results suggest that the mutagenesis by BUdR is associated with at least two nuclear genes, which replicate at two hr and three hr in the DNA synthesis period.
H J Burki, and
P M Aebersold
July 1976,
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik,
H J Burki, and
P M Aebersold
January 1985,
Radiobiologiia,
H J Burki, and
P M Aebersold
May 1987,
Mutation research,
H J Burki, and
P M Aebersold
July 1981,
Mutation research,
H J Burki, and
P M Aebersold
November 1978,
Mutation research,
H J Burki, and
P M Aebersold
December 1985,
Mutation research,
H J Burki, and
P M Aebersold
August 1982,
Mutation research,
H J Burki, and
P M Aebersold
October 1982,
Chemico-biological interactions,
H J Burki, and
P M Aebersold
September 1984,
Cancer research,
H J Burki, and
P M Aebersold
September 1977,
Genetics,
