Biomaterial Database

Renal tubular handling of zinc in the dog. 1981

W Victery, and J M Smith, and A J Vander

Clearance and stop-flow techniques, performed on anesthetized dogs, were used to obtain evidence for renal tubular reabsorption or secretion of 65Zn (administered intravenously with varying amounts of carrier ZnCl2). Ultrafilterability of plasma 65Zn was determined in vitro with Amicon CF-50A filter cones. Clearances were obtained under six conditions: antidiuresis, mannitol diuresis alone and following the infusion of chlorothiazide, citrate, cysteine, histidine. The percentage of ultrafilterability averaged, respectively, 1.15, 1.38, 0.91, 1.53, 19.90, and 11.61, while fractional zinc excretion averaged 0.046, 0.10, 0.31, 0.43, 0.78, and 0.12, respectively. Control stop-flow patterns invariably showed net Zn reabsorption in the distal nephron. Stop-flow patterns after chlorothiazide revealed significant net secretion in the far distal area in all animals. Patterns after either citrate or histidine infusion revealed significant net reabsorption in the proximal nephron. Those after cysteine were similar to the control patterns. Thus, both clearance and stop-flow experiments revealed net reabsorption as the major tubular mechanism of zinc handling, tubular secretion occurring only during chlorothiazide administration.

UI	MeSH Term	Description	Entries
D007444	Inulin	A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
D007684	Kidney Tubules	Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.	Kidney Tubule,Tubule, Kidney,Tubules, Kidney
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D014462	Ultrafiltration	The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.