Biomaterial Database

Effect of lung volume history on rate of edema formation in isolated canine lobe. 1978

H S Goldberg

The effect of lung volume history and prior accumulation of interstitial fluid on rate of edema formation in isolated canine lobes was investigated. Mean pulmonary artery pressure and mean pulmonary venous pressure were kept constant at 40 and 30 cmH2O, respectively. Transpulmonary pressure (Ptp) was varied among 5, 15, and 25 cmH2O by progressive stepwise inflation and deflation. Rate of fluid accumulation was estimated by changes in slow weight gain after a change in Ptp. Although there is continuous interstitial fluid accumulation over the course of the experiment the results indicate that interstitial hydrostatic pressure around leaky vessels at Ptp of 15 cmH2O is reduced by prior lung inflation to Ptp of 25 cmH2O and increased by prior deflation to Ptp of 5 cmH2O. These results suggest that the distribution of interstitial fluid may vary as a function of lung volume history.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005110	Extracellular Space	Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.	Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D005260	Female		Females