Biomaterial Database

Lung tissue volume during development of edema in isolated canine lungs. 1980

C R Felton, and W G Johanson

The technique of estimating pulmonary tissue volume (Vt) by rebreathing a tissue-soluble gas is rapid and noninvasive. We examined the sensitivity of this technique for the estimation of Vt in isolated, perfused canine lungs during the development of pulmonary edema. Vt was 84 +/- 15% (mean +/- SD) of the associated lung weight for lung weights of up to 240% of base line but decreased to 70 +/- 2% when lung weight exceeded 310% of base line. Small rebreathing tidal volumes resulted in significantly smaller values for Vt in edematous lungs. An abrupt increase in pulmonary venous pressure increased lung weight due to vascular distension; Vt measurements detected less than half of this increase, implying that certain portions of the intravascular blood volume are not measured by this technique.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008176	Lung Volume Measurements	Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.	Lung Capacities,Lung Volumes,Capacity, Lung,Lung Capacity,Lung Volume,Lung Volume Measurement,Measurement, Lung Volume,Volume, Lung
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000114	Acetylene	The simplest two carbon alkyne with the formula HCCH.	Ethyne
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013990	Tidal Volume	The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.	Tidal Volumes,Volume, Tidal,Volumes, Tidal