Physical work reduce insulinmia after glucose load, plasma cholesterol and triglycerides by intact rat at normal diet or diet enriched with sucrose, or beef fat, or both. By the male rat at normal diet or enriched with sucrose + beef fat castration increase insulin secretion. -1) Glycemia by those at work with diet rich in sucrose with or without beef fat, -2) Oestrogens increase triglyceridemia by castrated at diet rich in sucrose or beef fat but physical work suppress those increase. By the female at normal diet or enriched with sucrose and at recastration increase insulinemia after glucose load; castration increase insulinemia by female at work with diet enriched with beef fat or beef fat + sucrose. Castration increase the fall of triglyceridemia at work except by those at diet enriched with sucrose and those receiving testosterone and at diet enriched with sucrose + beef fat.