-transparent.png){kind=logo}
The purpose of this study, which involved 134 children aged between 0.5 and 17 years, was to investigate the metabolism of isoniazid (INH) in children and to provide guide-lines for dosage. The distribution of slow (55,5%) and fast (44,5%) acetylators was the same in children as in adults. However, the mean of INH inactivation index were lower (0.23 and 0.48) while distribution volumes, (1.30 +/- 0.06 and 1.57 +/- 0.17 1/kg) and total plasma clearances (5.39 +/- 0.43 and 14.7 +/- 1.5 ml/Kg/min) were higher than in adults. Plasma half-lives were similar in children and adults. These results indicate that INH is more rapidly metabolized in children owing, it is suggested to a higher liver weight : body weight ratio and to a more pronounced first pass effect. The doses of INH therefore must be higher in children and strictly adapted to each individual.
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
April 1979,
Monatsschrift fur Kinderheilkunde,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
January 1981,
Plucne bolesti i tuberkuloza,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
November 1979,
Praxis und Klinik der Pneumologie,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
August 1973,
Pneumonologie. Pneumonology,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
June 1974,
The Japanese journal of antibiotics,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
January 1976,
Casopis lekaru ceskych,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
August 1981,
Wiener medizinische Wochenschrift (1946),
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
February 1981,
The Japanese journal of antibiotics,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
February 1982,
Casopis lekaru ceskych,
C Advenier, and
A Saint-Aubin, and
P Scheinmann, and
J Paupe
January 1979,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
