-transparent.png){kind=logo}
A phase I clinical study of a combination of thymidine (TdR), inosine (IR), and allopurinol used as rescue from 24-hour infusions of methotrexate (MTX) was undertaken following animal studies that had shown a better preservation of antitumor activity with this system than with folinic acid. TdR and IR were given in the dose ratio 5:1 by weight throughout. Rescue from MTX, 400 mg/m2, could be achieved with a TdR dose in the combination of 1 g/m2/24 hours. This same rescue was also effective when the MTX dose was increased to 800 mg/m2, but only partly effective at an MTX dose of 1.5 g/m2. It was not necessary to raise the levels of circulating nucleosides significantly above normal to achieve rescue. MTX-related skin lesions occurred more frequently than might be expected with the MTX dose used.
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
March 1984,
Cancer treatment reports,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
November 1982,
Cancer research,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
August 1991,
Investigational new drugs,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
February 1992,
Transplantation,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
February 1978,
Cancer research,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
March 1978,
Cancer treatment reports,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
March 1983,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
March 1980,
Cancer,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
September 1978,
Cancer treatment reports,
P J Dady, and
G A Taylor, and
J F Muindi, and
A H Calvert, and
I E Smith, and
J F Smyth, and
K R Harrap
February 1979,
Cancer treatment reports,
