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The effect of staphylococcal alpha-toxin on the chemotactic response of human polymorphonuclear leukocytes was studied by measuring the migration of alpha-toxin-treated cells either through membrane filters toward C5a or under agarose toward N-formyl-l-methionyl-l-phenylalanine. At doses of greater than or equal to 5 hemolytic units, alpha-toxin depressed chemotactic responsiveness in both best systems. Further studies revealed that alpha-toxin was also a potent granulocyte aggregant at doses similar to those necessary for depressed chemotactic capacity. It is proposed that the inhibitory effect of this membrane-active toxin on chemotactic function may be related to increased granulocyte adhesiveness and that the pathogenic properties of alpha-toxin may in part by explained by these effects.
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
October 1972,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
January 1969,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
March 1967,
Science (New York, N.Y.),
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
July 1965,
Annals of the New York Academy of Sciences,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
April 1971,
Toxicon : official journal of the International Society on Toxinology,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
June 1972,
Toxicon : official journal of the International Society on Toxinology,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
September 1988,
Infection and immunity,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
December 1969,
Toxicon : official journal of the International Society on Toxinology,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
June 1968,
The Biochemical journal,
D J Schmeling, and
C G Gemmell, and
P R Craddock, and
P G Quie, and
P K Peterson
August 1976,
American journal of veterinary research,
