Biomaterial Database

Embryotoxicity of 9-(S)-(2,3-dihydroxypropyl)adenine. 1981

R Jelínek, and A Holý, and I Votruba

Embryotoxic properties of a novel nucleoside analog, 9-(S)-(2,3-dihydroxypropyl)adenine (DHPA), with powerful antiviral activity were estimated using the Chick Embryotoxicity Screening Test (CHEST). Exerting no substantial influence upon function of the caudal morphogenetic system on Day 1.5 (stages HH 10-11), the substance manifested strong embryotoxic action when administered in 30- and 100 microgram doses on Days 2 or 3. Deviant morphogenesis involved brain vesicles eyes, the face, body wall, extremities, the heart, and great vessels. The malformations often combined into the characteristic triad comprising microphthalmia, cleft beak, and reduction deformities of the limbs. Embryotoxic properties of an enantiomer (R)-DHPA were less frequently expressed, when compared with those of (S)-DHPA, parallelling their known antiviral activity. The effects of DHPA can be substantially reduced by simultaneous administration of adenine nucleosides. The distribution analysis of (S)-DHPA after application on Day 3 revealed most of the drug unchanged in the yolk and the embryo proper indicating that for expression of the embryotoxic properties no metabolic activation of DHPA was needed. As the embryotoxicity of DHPA was confirmed, even in mice, the biological effect of the drug seems to be of a general character.

UI	MeSH Term	Description	Entries
D007536	Isomerism	The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Isomerisms
D009024	Morphogenesis	The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000225	Adenine	A purine base and a fundamental unit of ADENINE NUCLEOTIDES.	Vitamin B 4,4, Vitamin B,B 4, Vitamin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus