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At several points during the growth of a clone of human embryonic lung fibroblasts in vitro, 100 to 200 cells were removed at random and the proliferative potential of each cell was determined. At each sample point, a wide variation in remaining population doubling ability was observed among the individual cells and the distributions of doubling potentials were distinctly bimodal. Furthermore, the two cells arising from a single mitosis differed in their ability to proliferate by as many as eight population doublings (256-fold in the number of cells produced). The results suggest that a stochastic process is responsible for determining the limited proliferative potential of human embryonic lung fibroblasts.
J R Smith, and
R G Whitney
May 1999,
Journal of theoretical biology,
J R Smith, and
R G Whitney
November 1974,
Biophysical journal,
J R Smith, and
R G Whitney
June 1982,
Experimental cell research,
J R Smith, and
R G Whitney
January 1992,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
J R Smith, and
R G Whitney
April 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
J R Smith, and
R G Whitney
January 1991,
Mutation research,
J R Smith, and
R G Whitney
November 2003,
Experimental cell research,
J R Smith, and
R G Whitney
December 1982,
Experimental cell research,
J R Smith, and
R G Whitney
April 1999,
Journal of theoretical biology,
J R Smith, and
R G Whitney
January 1971,
In vitro,
