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In a 1-year-old German boy a GPI deficiency was found to be the cause of a chronic nonspherocytic hemolytic anemia with recurrent hemolytic crises. Because of consanguinity of the parents, the patient is true homozygote. The investigation of the biochemical properties of the deficient enzyme revealed an altered electrophoretic behavior, pronounced thermolability, an increased affinity for G6P, an increased affinity for the competitive inhibitor 6-PG, and slightly changed pH optima for both substrates. Electrophoresis after freezing and thawing the hemolysate indicates that the genetic modification of the subunit involves the mechanism of transforming the main band into the secondary bands. The properties of the new deficient GPI indicate a new variant designated GPI Augsburg.
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
May 1983,
Blut,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
April 1977,
Klinische Wochenschrift,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
January 1990,
Pediatriia,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
February 1983,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
December 1997,
Blood cells, molecules & diseases,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
June 1994,
Harefuah,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
January 1974,
Pediatric research,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
February 1973,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
February 1973,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Arnold, and
G W Löhr, and
K Hasslinger, and
T Podgajny
June 1975,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
