-transparent.png){kind=logo}
The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results seem to support Essman's assumption that inhibition of brain protein synthesis by 5-HT may be responsible for the memory impairment. But also some other possibilities for a mechanism of 5-HT amnesia must be discussed.
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
April 1961,
Experimental neurology,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
April 1976,
Psychopharmacologia,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
April 1971,
Journal of comparative and physiological psychology,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
April 1982,
Physiology & behavior,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
October 1991,
Journal of neurochemistry,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
September 1981,
Pharmacology, biochemistry, and behavior,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
January 1970,
Radiobiologiia,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
June 1967,
British journal of pharmacology and chemotherapy,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
December 1970,
The Journal of pharmacy and pharmacology,
W Wetzel, and
V M Getsova, and
R Jork, and
H Matthies
January 2011,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
