Biomaterial Database

Lung deposition and clearance of cadmium in rats exposed by inhalation or by intratracheal instillation. 1980

G Oberdörster, and H Oldiges, and B Zimmermann

115mCdCl2 was nebulized by a jet nebulizer, yielding an aerosol concentration of Cd of 660 ng/l. Rats were exposed nose only for 1 h. For the instillation study 115mCdCl2 was instilled intracheally, 8 microgram in 0.3 ml NaCl. Rats of both studies were serially sacrificed from day 0-100, and the lung activity was counted. The results showed a bi-exponential clearance pattern in both studies, where the long clearance gave half lives of 61 d (inhalation) and 66 d (instillation), respectively. The short term clearance half lives were 1.1 d (inhalation) and 0.7 d (instillation). About half of the deposited Cd is cleared in both studies in the fast phase. After inhalation, 16% more Cd was deposited in the alveolar area as compared to instillation. It was found that on the second day after instillation of CdCl2 only 2% could be lavaged out of the lungs, suggesting a protein binding of Cd in the lung.

UI	MeSH Term	Description	Entries
D007267	Injections	Introduction of substances into the body using a needle and syringe.	Injectables,Injectable,Injection
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D002104	Cadmium	An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D000336	Aerosols	Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.	Aerosol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014132	Trachea	The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.	Tracheas