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A prospective study of 2191 Negro infants in Jamaica showed that approximately 7% of them had detectable levels of Hb Bart's (gamma 4) in the neonatal period. The red cell indices, globin chain biosynthesis and restriction endonuclease mapping of DNA from these infants were used to determine the significance of Hb Bart's at birth. The results indicate that the genotypes alpha alpha/alpha alpha, -- alpha/alpha alpha and -- alpha/ -- alpha are associated with 0%, 0.1-2%, and greater than 2% Hb Bart's respectively. Although trace amounts of Hb Bart's may be associated with the genotype -- alpha/alpha alpha this is not always the case and therefore haemoglobin analysis in the neonatal period cannot be used to diagnose this genotype with any certainty.
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
December 1974,
Pediatric research,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
October 1980,
Journal of medical genetics,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
August 1980,
Journal of medical genetics,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
December 1974,
British journal of haematology,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
March 1993,
Bailliere's clinical haematology,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
March 1998,
Bailliere's clinical haematology,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
August 2008,
Seminars in fetal & neonatal medicine,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
May 2010,
Orphanet journal of rare diseases,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
October 1952,
British medical journal,
D R Higgs, and
L Pressley, and
J B Clegg, and
D J Weatherall, and
S Higgs, and
P Carey, and
G R Serjeant
July 1959,
Pediatrics,
