Interaction of atopy and exposure to cotton dust in the bronchoconstrictor response. 1980

R N Jones, and B T Butcher, and Y Y Hammad, and J E Diem, and H W Glindmeyer, and S B Lehrer, and J M Hughes, and H Weill

A survey of 255 workers in four cottonseed crushing mills included a respiratory health questionnaire, allergy skin testing, and measurements of lung function over the Monday working shift. Atopy was defined as having two or more positive weal reactions to common inhalant antigens. Categories of exposure to dust were based on the stage of milling, and one category contained workers with continuous exposure to cotton dust derived from linters, the cotton fibres adherent to cottonseed. Atopy and exposure to dust were found to have significant interaction: large mean declines in FEV1 and FEF 25-75 occurred only in the workers exposed to linter dust who were also atopic. Skin-testing surveys in cotton textile mills have concentrated on specific cotton antigen reactivity and its first-order relations to symptoms. Our results indicate a need to identify atopic workers, and to search for interactions between atopy and other variables that may influence acute changes in expiratory flow rates.

UI MeSH Term Description Entries
D006969 Hypersensitivity, Immediate Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability. Atopic Hypersensitivity,Hypersensitivity, Atopic,Hypersensitivity, Type I,IgE-Mediated Hypersensitivity,Type I Hypersensitivity,Atopic Hypersensitivities,Hypersensitivities, Atopic,Hypersensitivities, IgE-Mediated,Hypersensitivities, Immediate,Hypersensitivities, Type I,Hypersensitivity, IgE-Mediated,IgE Mediated Hypersensitivity,IgE-Mediated Hypersensitivities,Immediate Hypersensitivities,Immediate Hypersensitivity,Type I Hypersensitivities
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D009787 Occupational Medicine Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings. Industrial Medicine,Medicine, Industrial,Medicine, Occupational
D003368 Gossypium A plant genus of the family MALVACEAE. It is the source of COTTON FIBER; COTTONSEED OIL, which is used for cooking, and GOSSYPOL. The economically important cotton crop is a major user of agricultural PESTICIDES. Cotton Plant,Cotton Plants,Gossypiums,Plant, Cotton,Plants, Cotton
D005260 Female Females
D005540 Forced Expiratory Flow Rates The rate of airflow measured during a FORCED VITAL CAPACITY determination. Expiratory Forced Flow Rates,Flow Rates, Expiratory Forced,Flow Rates, Forced Expiratory
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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