-transparent.png){kind=logo}
Each of 6 rats with a low grade of ANIT-cholestasis and a low grade of GalN-hepatitis received either 3 mg Lidocain i.v. or 24 mg Lidocain orally. The plasma concentrations of Lidocain were measured over a period of 3 1/2 hrs. The systemic clearance of Lidocain (Cli.v. = Di.v. divided by AUCi.v.) was significantly increased on ANIT-cholestasis (17 +/- 3) and GalN-hepatitis rats (13 +/- 2) (control rats: 7 +/- 1 ml/min x 100 g bw). Oral clearance of Lidocain (Clor = Dor divided by AUCor) was not significantly different in the three respective groups. In both groups with experimental liver disease the hepatic blood flow--calculated by comparing the systemic to the oral clearance--was significantly increased (22 +/- 4 and 19 +/- 3 vs 8 +/- 1 ml/min x 100 g bw). Due to this increase, the hepatic extraction ratio of Lidocain was significantly decreased (ANIT-cholestasis 0.73 +/- 0.07; GalN-hepatitis 0.74 +/- 0.05; controls 0.85 +/- 0.03). Because of an increase of systemic Lidocain clearance, no toxic plasma concentrations were observed.
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
October 1979,
Zeitschrift fur Gastroenterologie,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
June 1973,
Fortschritte der Medizin,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
January 1979,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
June 1977,
Zeitschrift fur Gastroenterologie,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
January 1981,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
May 1972,
Klinische Wochenschrift,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
August 2013,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
February 1977,
Wiener klinische Wochenschrift,
M Fuchshofen, and
H Heusler, and
B Lutz, and
E Mora, and
E Richter
April 1979,
Radiobiologia, radiotherapia,
