Effects of phosphate loading and parathyroid hormone on starling renal phosphate excretion. 1980

R F Wideman, and N B Clark, and E J Braun

The effects of phosphate loading were examined in intact, parathyroidectomized (PTX), and PTX starlings infused with parathyroid extract (PTX +/- PTE). In intact starlings, there was no correlation between the filtered phosphate load and the quantity of phosphate excreted. Net secretion predominated at lower filtered loads (2.5-20 mu mol . kg-1 . min-1) but net reabsorption occurred at filtered loads between 20 and 35 mu mol . kg-1 . min-1. Phosphate-loaded PTX starlings reabsorb phosphate over a wide range of filtered loads (5-45 mu mol . kg-1 . min-1). Excretion was significantly correlated with the filtered load in PTX birds (r = 0.943). Phosphate loaded PTX + PTE starlings secreted phosphate when filtered loads ranged from 2.5 to 30 mu mol . kg-1 . min-1. Excretion also was significantly correlated with the filtered load in this group (r = 0.972). The results of these experiments indicate that a) variations in endogenous PTH release in intact starlings result in wide variations in the renal pattern of phosphate excretion during phosphate loading; b) net phosphate secretion rarely occurs during phosphate loading in PTX starlings, but always occurs in PTX + PTE starlings; and c) both phosphate secretion and phosphate reabsorption are limited by maximal tubular transport capacities. Additional evidence indicates that PTH inhibits tubular phosphate reabsorption in starlings.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D010280 Parathyroid Glands Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body. Gland, Parathyroid,Glands, Parathyroid,Parathyroid Gland
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D010710 Phosphates Inorganic salts of phosphoric acid. Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic
D001717 Birds Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves. Aves,Bird

Related Publications

R F Wideman, and N B Clark, and E J Braun
January 1970, The Mount Sinai journal of medicine, New York,
R F Wideman, and N B Clark, and E J Braun
March 1953, The Journal of clinical endocrinology and metabolism,
R F Wideman, and N B Clark, and E J Braun
January 1986, The American journal of physiology,
R F Wideman, and N B Clark, and E J Braun
April 1957, The Journal of clinical investigation,
R F Wideman, and N B Clark, and E J Braun
May 2023, Acta physiologica (Oxford, England),
R F Wideman, and N B Clark, and E J Braun
December 1974, The American journal of physiology,
R F Wideman, and N B Clark, and E J Braun
May 1951, The American journal of physiology,
R F Wideman, and N B Clark, and E J Braun
November 1990, Archives of disease in childhood,
R F Wideman, and N B Clark, and E J Braun
May 1977, Metabolism: clinical and experimental,
R F Wideman, and N B Clark, and E J Braun
October 1981, General and comparative endocrinology,
Copied contents to your clipboard!