Biomaterial Database

The fine structure of neurofibrillary tangles in a case of atypical presenile dementia. 1980

S Yagishita, and Y Itoh, and N Amano, and T Nakano

The neurofibrillary tangles in a case of atypical presenile dementia were studied by electron microscopy. The tangles consisted of 2 types of tubule: one straight, measuring about 15--20 nm in width, the other twisted. Both types of tubule appeared separately in each neuron; however, occasionally twisted tubules seemed to be distributed among the straight tubules. The implications of these findings are briefly discussed.

UI	MeSH Term	Description	Entries
D008870	Microtubules	Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.	Microtubule
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009454	Neurofibrils	The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the CYTOPLASM of the body of a NEURON and extending from one DENDRITE into another or into the AXON.	Neurofibril
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D003704	Dementia	An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D005260	Female		Females
D005625	Frontal Lobe	The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.	Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000425	Alcohol Amnestic Disorder	A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)	Alcohol-Induced Amnestic Syndrome,Amnestic Psychosis, Alcohol-Induced,Alcohol Amnestic Syndrome,Alcohol-Induced Amnestic Psychosis,Alcohol-Induced Dysmnesic Psychosis,Alcohol-Induced Dysmnesic Syndrome,Alcohol-Induced Persisting Amnestic Disorder,Alcohol Amnestic Disorders,Alcohol Amnestic Syndromes,Alcohol Induced Amnestic Psychosis,Alcohol Induced Amnestic Syndrome,Alcohol Induced Dysmnesic Psychosis,Alcohol Induced Dysmnesic Syndrome,Alcohol Induced Persisting Amnestic Disorder,Alcohol-Induced Amnestic Psychoses,Alcohol-Induced Amnestic Syndromes,Alcohol-Induced Dysmnesic Psychoses,Alcohol-Induced Dysmnesic Syndromes,Amnestic Disorder, Alcohol,Amnestic Psychoses, Alcohol-Induced,Amnestic Psychosis, Alcohol Induced,Amnestic Syndrome, Alcohol-Induced,Amnestic Syndromes, Alcohol-Induced,Dysmnesic Psychoses, Alcohol-Induced,Dysmnesic Psychosis, Alcohol-Induced,Dysmnesic Syndrome, Alcohol-Induced,Dysmnesic Syndromes, Alcohol-Induced,Psychoses, Alcohol-Induced Amnestic,Psychoses, Alcohol-Induced Dysmnesic,Psychosis, Alcohol-Induced Amnestic,Psychosis, Alcohol-Induced Dysmnesic