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The fine structure of "Pittsburgh Pneumonia Agent" (PPA) was studied in infected human lung, guinea pig omentum, yolk sac membrane, Vero cell culture, and after cultivation of the organism on buffered charcoal yeast extract agar. The organism is a prokaryotic cell with the general features of a gram-negative bacillus. PPA is ultrastructurally distinctive because of an unusually thick, electron-dense band present within the periplasmic space adjacent to the outer membrane of the cell wall. This band, presumably a mucopeptide (peptidoglycan) layer, was seen in about 95% of organisms in human lung but less frequently under certain conditions of laboratory infection or cultivation. Future studies are required to determine whether this ultrastructural dimorphism of PPA is related to variation in other properties of this bacterium, eg, gram-variability, acid-fastness, colony morphology, and virulence.
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
January 1980,
Duodecim; laaketieteellinen aikakauskirja,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
October 1980,
Medicina clinica,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
March 1983,
JAMA,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
December 1987,
Seminars in respiratory infections,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
March 1984,
Radiology,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
February 1982,
AJR. American journal of roentgenology,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
November 1981,
British medical journal (Clinical research ed.),
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
April 1983,
The American journal of medicine,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
November 1981,
The American journal of medicine,
F M Gress, and
R L Myerowitz, and
A W Pasculle, and
C R Rinaldo, and
J N Dowling
November 1979,
The New England journal of medicine,
