Biomaterial Database

Pharmacological disposition of negatively charged phospholipid vesicles in rats. 1980

Y J Kao, and T L Loo

The pharmacological disposition of four negatively charged phospholipid vesicles with radioactive cholesteryl oleate as a tracer was investigated in rats. The acidic phospholipids included phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and diphosphatidylglycerol (cardiolipin). The blood half-life of phosphatidylserine vesicles was the shortest (< 2 min), while that of phosphatidylinositol was the longest (90 min). Cardiolipin and phosphatidylglycerol vesicles had intermediate blood half-lives (7 and 18 min, respectively). The distribution of these vesicles in six major organs (liver, spleen, heart, kidneys, lungs, and brain) varied greatly. Contrary to the long-held belief, it was possible to prepare negatively charged phospholipid vesicles with long blood half-lives. Furthermore, tissue disposition of these negatively charged vesicles could be manipulated partially by judicious selection of their components.

UI	MeSH Term	Description	Entries
D008081	Liposomes	Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.	Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D010743	Phospholipids	Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.	Phosphatides,Phospholipid
D006207	Half-Life	The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.	Halflife,Half Life,Half-Lifes,Halflifes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus