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The present work was performed to evaluate the participation of the benzodiacepinic GABAA and GABAB components upon excessive grooming, locomotion, rearing, and stretching/yawning syndrome induced by the intracerebroventricularly alpha-MSH administration by using GABAA and GABAB agonists. It also aims at evaluating possible relation between changes in cAMP levels in caudate-putamen and accumbens nuclei and the behavioral responses. Injection of diazepam or baclofen reduced the total behavioral scores in a dose-related manner as well as the cAMP levels with respect to the control values (animals treated with artificial cerebrospinal fluid). When diazepam was tested in animals simultaneously injected with alpha-MSH, behavioral scores decreased with respect to those treated with the peptide alone. Cyclic AMP also decreased after combined treatment (MSH + diazepam).
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1996,
Peptides,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1995,
Peptides,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1976,
Pharmacology, biochemistry, and behavior,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1996,
Peptides,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1974,
Recent progress in hormone research,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
May 1993,
Annals of the New York Academy of Sciences,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1993,
Peptides,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
January 1978,
International archives of allergy and applied immunology,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
December 1981,
Bollettino della Societa italiana di biologia sperimentale,
C Cremer, and
S R de Barioglio, and
G Civallero, and
M E Celis
November 1982,
Life sciences,
