-transparent.png){kind=logo}
Gangliosides are particularly enriched in neuron cell membranes and they were postulated to be involved in the modulation of membrane-mediated transduction of information. In this study we explore the possibility that the increase in cAMP tissular levels induced by alpha-MSH may be modulated by the action of exogenously added gangliosides. We measured the level of cAMP in both tissues and medium in response to the alpha-MSH in slices previously incubated with total bovine brain gangliosides (TBG). When slices were exposed to TBG, the effect of alpha-MSH on inducing an increase in the content of cAMP was practically twice compared to the changes induced by alpha-MSH or TBG alone. We conclude that the presence of gangliosides may facilitate the alpha-MSH interaction with its receptor, increasing the cAMP levels in slices containing the CP and Acc nuclei.
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
May 1993,
Annals of the New York Academy of Sciences,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
January 1993,
Peptides,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
January 1995,
Peptides,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
January 1976,
Pharmacology, biochemistry, and behavior,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
September 1980,
Life sciences,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
September 1977,
Life sciences,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
February 1985,
Pharmacology, biochemistry, and behavior,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
January 1996,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
January 1995,
Peptides,
N E Lezcano, and
M González, and
G D Fidelio, and
M E Celis
September 1973,
Brain research,
