-transparent.png){kind=logo}
OBJECTIVE Dimethyl sulfoxide (DMSO), an agent that provides symptomatic relief in patients with interstitial cystitis (IC) works via an unknown mechanism. We investigated whether DMSO acts as a chemical stimulant of mast cell degranulation. METHODS A radioimmunoassay (RIA) specific for histamine was used to test this hypothesis. Twelve women with strictly diagnosed IC were treated with intravesical instillations of DMSO. Treatments were repeated at varying intervals, and each patient received three to six treatments. Urine histamine levels were measured before and after each intravesical instillation of DMSO. Dilutional effects of DMSO were corrected for by conversion of urine histamine concentration to urine histamine:creatinine ratio. RESULTS The RIA was unaffected by the addition of DMSO to urine. No consistent change in the urine histamine:creatinine ratio following DMSO instillation was found. Trend analysis revealed no trend in the histamine:creatinine ratio with time. CONCLUSIONS The relief of symptoms reported in 50% to 77% of patients treated with intravesical DMSO is not related to detectable mast cell release of histamine. Other mechanisms of action must be investigated to explain the beneficial effect of this agent.
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
October 1992,
The Journal of urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
August 1978,
The Medical letter on drugs and therapeutics,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
January 1991,
Actas urologicas espanolas,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
July 1988,
The Journal of urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
July 1986,
Urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
May 1997,
Urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
August 1994,
The Journal of urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
April 1987,
Urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
June 1995,
The Journal of urology,
L Stout, and
J M Gerspach, and
S M Levy, and
S K Yun, and
P M Lad, and
G E Leach, and
P E Zimmern
January 1978,
Scandinavian journal of urology and nephrology,
