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We examined the effects of adenosine A1 and A2 receptor agonists on LPS-stimulated TNF alpha production by human monocytes isolated from peripheral blood. We have demonstrated that CGS-21680, a highly selective A2 agonist inhibited production of TNF alpha at the protein level by 75% whereas the A1 selective agonist N6 reduced TNF alpha production by only 25%. The action of CGS-21680 was mediated via the A2 receptors since its effect on TNF production was blocked by 3,7-dimethyl-1-propargylxanthine (DMPX) but not by xanthine amine cogener (XAC), antagonists selective for the A2 and A1 receptors, respectively. Thus intervention with A2-selective agonists or compounds that can elevate endogenously released adenosine may be beneficial in TNF alpha-mediated diseases.
U Prabhakar, and
D P Brooks, and
D Lipshlitz, and
K M Esser
January 1993,
Life sciences,
U Prabhakar, and
D P Brooks, and
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K M Esser
June 2004,
American journal of physiology. Cell physiology,
U Prabhakar, and
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Veterinary immunology and immunopathology,
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The Journal of laboratory and clinical medicine,
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Phytomedicine : international journal of phytotherapy and phytopharmacology,
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Cytokine,
U Prabhakar, and
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American journal of physiology. Regulatory, integrative and comparative physiology,
U Prabhakar, and
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U Prabhakar, and
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August 1984,
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