-transparent.png){kind=logo}
Inhibition of breast and ovarian carcinoma cell growth by 1,25-dihydroxyvitamin D3 combined with retinoic acid or dexamethasone. 1995
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
CS Mott Center, Department of OB/GYN, Wayne State University, Detroit, MI 48201, USA.
This study examined the growth inhibitory effects of combining 1,25-dihydroxyvitamin D3 (calcitriol) with retinoic acid or dexamethasone against cultured breast and ovarian carcinoma cells. Retinoic acid (12.5-50 nM) increased the effectiveness of calcitriol (12.5-50 nM) against MCF-7 and NIH:OVCAR3 cells, with synergistic interactions at two of the three ratios tested. Dexamethasone augmented calcitriol effects, with synergism at 0.05 and 0.1 nM dexamethasone in MCF-7 cells and 5 nM in Caov-4 ovarian cells. This study showed favorable interactions for calcitriol-retinoic acid and calcitriol-dexamethasone combinations in breast and ovarian cancer cell lines.
Related Publications
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
September 1983,
Cancer research,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
October 1991,
The Journal of steroid biochemistry and molecular biology,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
January 1990,
Bone,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
July 2020,
Oncotarget,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
November 1986,
Endocrinology,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
April 2000,
Cancer research,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
October 1992,
Journal of nutritional science and vitaminology,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
June 1985,
Cancer letters,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
August 2007,
Haematologica,
D E Saunders, and
C Christensen, and
J R Williams, and
N L Wappler, and
W D Lawrence, and
J M Malone, and
V K Malviya, and
G Deppe
January 1994,
The Journal of biological chemistry,
