Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin. 1995

P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
Dept of Biochemistry, Szent-Györgyi University, Szeged, Hungary.

We investigated whether nitroglycerin (NTG) was able to produce an anti-ischaemic effect in isolated working hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non-tolerant rats were subjected to 10 min coronary occlusion in the presence of 10(-7) M NTG and/or its solvent. NTG alleviated ischaemia-induced deterioration of cardiac function and decreased lactate dehydrogenase release whilst having no effect on coronary flow nor the area of the ischaemic zone both in hearts isolated from NTG-tolerant and non-tolerant rats. The magnitude of the effect was similar in the two groups. These results suggest that the anti-ischaemic effect of NTG involves direct myocardial mechanisms independent of its vascular action and that vascular tolerance to NTG does not affect this direct protective action.

UI MeSH Term Description Entries
D008297 Male Males
D003331 Coronary Vessels The veins and arteries of the HEART. Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004361 Drug Tolerance Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL. Drug Tolerances,Tolerance, Drug,Tolerances, Drug
D005996 Nitroglycerin A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Glyceryl Trinitrate,Anginine,Dynamite,Gilustenon,Nitrangin,Nitro-Bid,Nitro-Dur,Nitrocard,Nitroderm,Nitroderm TTS,Nitroglyn,Nitrol,Nitrolan,Nitrong,Nitrospan,Nitrostat,Perlinganit,Susadrin,Sustac,Sustak,Sustonit,Transderm Nitro,Tridil,Trinitrin,Trinitrolong,Nitro Bid,Nitro Dur,NitroBid,NitroDur,Trinitrate, Glyceryl
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014665 Vasodilator Agents Drugs used to cause dilation of the blood vessels. Vasoactive Antagonists,Vasodilator,Vasodilator Agent,Vasodilator Drug,Vasorelaxant,Vasodilator Drugs,Vasodilators,Vasorelaxants,Agent, Vasodilator,Agents, Vasodilator,Antagonists, Vasoactive,Drug, Vasodilator,Drugs, Vasodilator
D017202 Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). Heart Disease, Ischemic,Ischemia, Myocardial,Ischemic Heart Disease,Disease, Ischemic Heart,Diseases, Ischemic Heart,Heart Diseases, Ischemic,Ischemias, Myocardial,Ischemic Heart Diseases,Myocardial Ischemias
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
May 1984, Cardiovascular research,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
October 1992, The Annals of thoracic surgery,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
November 1988, European journal of pharmacology,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
March 1982, Cardiovascular research,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
January 1982, Life sciences,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
January 2017, PloS one,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
October 2002, Expert opinion on therapeutic targets,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
July 2008, Cardiovascular research,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
August 2014, Trends in pharmacological sciences,
P Ferdinandy, and Z Szilvássy, and T Csont, and C Csonka, and E Nagy, and M Koltai, and L Dux
August 1994, British journal of pharmacology,
Copied contents to your clipboard!