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A preceding right ventricular overdrive pacing (VOP) of 500 b.p.m. for 5 min, markedly reduced the severity of global myocardial ischaemia produced by a subsequent 5-min VOP in conscious rabbits. This VOP-induced preconditioning developed in parallel with an increase in cardiac cyclic guanosine 3':5'-monophosphate (cyclic GMP) content. VOP-induced preconditioning was abolished when the animals had been made tolerant to the vasodilator effect of nitroglycerin (NG). In the heart of the NG-tolerant rabbits, neither VOP nor preconditioning increased cyclic GMP content. This suggests that changes by NG tolerance of cyclic GMP metabolism may account for the loss of VOP-induced preconditioning.
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
February 2010,
American journal of physiology. Heart and circulatory physiology,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
August 2001,
Circulation,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
July 2008,
Cardiovascular research,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
February 2010,
American journal of physiology. Heart and circulatory physiology,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
December 1987,
Archives internationales de pharmacodynamie et de therapie,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
May 2005,
Circulation,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
August 1995,
British journal of pharmacology,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
June 1994,
Anesthesia and analgesia,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
June 1982,
The Journal of pharmacology and experimental therapeutics,
Z Szilvassy, and
P Ferdinandy, and
P Bor, and
I Jakab, and
J Szilvassy, and
I Nagy, and
J Lonovics, and
M Koltai
May 2000,
British journal of pharmacology,
