-transparent.png){kind=logo}
Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13. 1995
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
Department of Pathology, University Hospital of Iceland, Reykjavik, Iceland.
In this study we examined loss of heterozygosity (LOH) on chromosome 13q12-13 in 50 tumors from BRCA2 carriers in five families showing strong evidence of linkage to BRCA2. In addition to high frequency of LOH in female breast cancer, LOH was observed in tumors of the prostate, ovary, cervix, colon, male breast, and ureter. All detected losses involved the wild-type chromosome. These results suggest that BRCA2 is a tumor suppressor gene and may be involved in the tumorigenesis of several cancer types in addition to breast cancer.
Related Publications
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
August 1996,
Genomics,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
November 1995,
British journal of cancer,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
April 1995,
Oncogene,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
September 1994,
Science (New York, N.Y.),
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
July 1997,
American journal of human genetics,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
October 1995,
Cancer research,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
November 1996,
British journal of cancer,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
September 2017,
BMC cancer,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
February 1998,
Diagnostic molecular pathology : the American journal of surgical pathology, part B,
J Gudmundsson, and
G Johannesdottir, and
J T Bergthorsson, and
A Arason, and
S Ingvarsson, and
V Egilsson, and
R B Barkardottir
January 2002,
Cytogenetic and genome research,
