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Two case reports describing the treatment of digitoxin toxicity with cholestyramine resin are presented. Both female patients were receiving 100 microgram/day of digitoxin when toxicity occurred. In both patients, digitoxin was discontinued and hypokalemia was corrected. In patient 1, lidocaine hydrochloride and phenytoin sodium also were administered. Serum digitoxin levels were decreased from 43 ng/ml to 21.8 ng/ml and from 42 ng/ml to 29 ng/ml in patients 1 and 2, respectively, following administration of three 4-g doses of cholestyramine resin over a one-day period. Previous studies on the treatment of digitoxin intoxication with potassium chloride, phenytoin sodium, lidocaine hydrochloride, digitoxin-specific antibodies, colestipol hydrochloride and cholestyramine resin are discussed. Ion-exchange resins may be valuable adjuncts in the treatment of digitoxin intoxication but further studies of their utility are needed.
W J Cady, and
T L Rehder, and
J Campbell
May 1981,
JAMA,
W J Cady, and
T L Rehder, and
J Campbell
January 1983,
Drug intelligence & clinical pharmacy,
W J Cady, and
T L Rehder, and
J Campbell
June 1974,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
W J Cady, and
T L Rehder, and
J Campbell
May 1967,
Archives internationales de pharmacodynamie et de therapie,
W J Cady, and
T L Rehder, and
J Campbell
March 1978,
Lancet (London, England),
W J Cady, and
T L Rehder, and
J Campbell
October 1984,
International journal of clinical pharmacology, therapy, and toxicology,
W J Cady, and
T L Rehder, and
J Campbell
December 1971,
The Journal of clinical investigation,
W J Cady, and
T L Rehder, and
J Campbell
February 1980,
Clinical pharmacology and therapeutics,
W J Cady, and
T L Rehder, and
J Campbell
September 1978,
The Johns Hopkins medical journal,
