-transparent.png){kind=logo}
Pulmonary capillary pressure (Ppc), the major factor responsible for pulmonary edema, cannot be directly measured in intact subjects but may be estimated by analysis of the pressure decay profile after pulmonary artery catheter balloon inflation. We compared three different methods of pulmonary artery occlusion pressure (Ppao) decay profile analysis to estimates of Ppc derived from lymph flow measurements in halothane-anesthesized sheep. The relationship between Ppc and lymph flow was first determined by increasing Ppc by left atrial balloon inflation, and was then used to determine Ppc during pulmonary hypertension produced by infusion of a thromboxane analog. All three methods of Ppao decay profile analysis demonstrated a correlation with Ppc estimated from lymph flow. However, the method using a single exponential analysis significantly overestimated Ppc, and none of the methods reliably estimated changes in the longitudinal distribution of pulmonary vascular resistance during pulmonary hypertension. These results suggest that Ppao decay profile analysis as currently performed has limited application.
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
January 1986,
Critical care medicine,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
January 1993,
Anesthesia and analgesia,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
December 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
August 1983,
The American review of respiratory disease,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
January 2003,
Intensive care medicine,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
February 1988,
Anesthesiology,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
October 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
November 1983,
Chest,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
November 1989,
The American review of respiratory disease,
G E Wakerlin, and
J C Finn, and
L C Siegel, and
G V Benson, and
T F Flavin, and
R G Pearl
June 1994,
Critical care medicine,
