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Oligonucleotides 5'-d(CT)5-L-d(AG)5-L-d(GA)5-3' and 5'-d(GA)5-L-d(TC)5-L-d(GA)5-3' [L = pO(CH2CH2O)3p] were studied by thermal denaturation, chemical modification and binding of fluorescent dyes. Both oligonucleotides are shown to fold back on itself twice forming at pH 7 a sufficiently stable triplex ether with antiparallel-oriented oligopurine strands (the first compound) or parallel-oriented oligopurine strands (the second compounds). The parallel triplex is significantly less stable than the antiparallel one. On the basis of conformational modeling, possible types of base tripling in the triplets are proposed. Thus our data provide the first convincingly evidence for the existence of a purine-pyrimidine-purine triplex with parallel orientation of identical strands.
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
January 1993,
Nucleic acids research,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
February 1993,
Nucleic acids research,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
June 1995,
The Journal of biological chemistry,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
October 1995,
Nucleic acids research,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
January 1997,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
August 1994,
Nucleic acids research,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
January 1989,
Doklady Akademii nauk SSSR,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
April 1996,
Journal of molecular biology,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
November 1995,
Nucleic acids research,
A K Shchyolkina, and
O F Borisova, and
E E Minyat, and
E N Timofeev, and
I A Il'icheva, and
E B Khomyakova, and
V L Florentiev
September 2005,
Journal of the American Chemical Society,
