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In a group of 50 neurosurgical patients receiving sodium nitroprusside as a hypotensive agent, in doses of 50--2131 microgram/kg body weight, whole blood cyanide was estimated before infusion of drug, during infusion, immediately after infusion, and 1 and 3 h later. Cyanide values increased significantly, reaching the maximum in a sample taken immediately after infusion (mean value, 333; highest value, 1800 microgram/liter). Values correlated closely with both dose and rate of infusion. Blood thiocyanate, estimated before, immediately after, and 3 h after the infusion, showed no significant changes in thiocyanate concentration. In any case, no signs or symptoms of cyanide or thiocyanate poisoning were observed. We conclude that sodium nitroprusside, in the proper dose and given at the proper rate, does not precipitate cyanide poisoning.
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
July 1976,
British journal of anaesthesia,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
February 1985,
British journal of anaesthesia,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
October 1968,
British journal of anaesthesia,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
October 1991,
Pediatric cardiology,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
May 1987,
British journal of anaesthesia,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
October 1970,
British journal of anaesthesia,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
January 1962,
Anesthesiology,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
October 1979,
Acta anaesthesiologica Scandinavica,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
September 1979,
Canadian Anaesthetists' Society journal,
M Bogusz, and
J Moroz, and
J Karski, and
J Gierz, and
A Regieli, and
R Witkowska, and
Gołabek
September 1974,
Postgraduate medical journal,
