-transparent.png){kind=logo}
Decorin mRNA levels, the content of decorin and the synthesis of dermatan sulphate in skin fibroblasts from patients with systemic and localized scleroderma were investigated. Approximately a 2.2-fold increase in decorin mRNA levels, was found by Northern blot analysis in localized scleroderma, but no significant changes were found in systemic scleroderma. Decorin, as measured by an immunoblot assay, was increased 2.6-fold in fibroblast cultures from localized scleroderma but not in those from systemic scleroderma. In contrast, the synthesis of dermatan sulphate was similar in both conditions. These results indicate that altered decorin gene expression causes abnormal proteoglycan metabolism in localized scleroderma.
T Izumi, and
S Tajima, and
T Nishikawa
January 1988,
Dermatologica,
T Izumi, and
S Tajima, and
T Nishikawa
June 2007,
Journal of the American Academy of Dermatology,
T Izumi, and
S Tajima, and
T Nishikawa
November 2023,
Intractable & rare diseases research,
T Izumi, and
S Tajima, and
T Nishikawa
February 1991,
The Journal of rheumatology,
T Izumi, and
S Tajima, and
T Nishikawa
January 1995,
Clinical and experimental rheumatology,
T Izumi, and
S Tajima, and
T Nishikawa
April 1990,
Clinical science (London, England : 1979),
T Izumi, and
S Tajima, and
T Nishikawa
September 1996,
Archives of dermatological research,
T Izumi, and
S Tajima, and
T Nishikawa
April 1995,
The Journal of investigative dermatology,
T Izumi, and
S Tajima, and
T Nishikawa
August 1990,
Biokhimiia (Moscow, Russia),
T Izumi, and
S Tajima, and
T Nishikawa
March 2001,
Arthritis and rheumatism,
