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We reported that PuO2 reflects renal medullary perfusion and decreases during N2O-O2 isoflurane (GOI) or sevoflurane (GOS) anesthesia. In the present study, we examined the effect of dopamine (DOA) or prostaglandin E1 (PGE1) on PuO2 during GOI anesthesia. Twenty four patients from elective surgery with GOI anesthesia were randomly divided into three groups, i.e. control group (n = 8), DOA group (n = 8) and PGE1 group (n = 8). PuO2 decreased significantly in the control group, while in the DOA and PGE1 groups, PuO2 was unchanged. These results suggest that DOA and PGE1 maintain renal medullary perfusion under GOI anesthesia.
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