Transforming growth factor beta secretion from primary breast cancer fibroblasts. 1995

C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
Department of Medical Oncology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

Transforming growth factor beta (TGF-beta) is a hormonally regulated growth inhibitor with autocrine and/or paracrine functions in human breast cancer. In vivo, enhanced immunohistochemical staining of extracellular TGF-beta 1 has been detected around stromal fibroblasts in response to the antiestrogen treatment. We have investigated the effects of tamoxifen on the production of TGF-beta by primary human breast fibroblast cultures in serum-free medium. Highly variable levels of mainly latent TGF-beta 1 were detected in conditioned media from both tumor and normal tissue derived fibroblasts. Hydroxy-tamoxifen was shown to increase latent TGF-beta 1 secretion in three of the eight tumor tissue-derived fibroblast cultures. Such effect of hydroxy-tamoxifen was not observed in fibroblast cultures established from normal adjacent breast tissue.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008907 Mink Carnivores of genera Mustela and Neovison of the family MUSTELIDAE. The European mink has white upper and lower lips while the American mink lacks white upper lip. American Mink,European Mink,Mustela lutreola,Mustela macrodon,Mustela vison,Neovison vison,Sea Mink,Mink, American,Mink, European,Mink, Sea,Minks,Minks, Sea,Sea Minks,vison, Neovison
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001681 Biological Assay A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc. Bioassay,Assay, Biological,Assays, Biological,Biologic Assay,Biologic Assays,Assay, Biologic,Assays, Biologic,Bioassays,Biological Assays

Related Publications

C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
January 2005, Cancer treatment and research,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
January 2000, Breast cancer research : BCR,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
January 2000, Breast cancer research : BCR,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
December 2008, Korean journal of ophthalmology : KJO,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
February 1991, The American journal of physiology,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
December 1994, British journal of cancer,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
May 2007, Frontiers in bioscience : a journal and virtual library,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
January 2000, Breast cancer research : BCR,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
September 1990, British journal of cancer,
C E van Roozendaal, and J G Klijn, and B van Ooijen, and C Claassen, and A M Eggermont, and S C Henzen-Logmans, and J A Foekens
January 1993, Anticancer research,
Copied contents to your clipboard!