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The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nonanone and 5-methyl-2-(3-oxobutyl)furan. Metabolism strongly favored the formation of monoalcohols and lactones, which are the products of appropriately substituted hydroxy carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines.
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
May 1986,
Toxicology letters,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
January 1988,
Journal of toxicology and environmental health,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
August 1987,
Toxicology letters,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
January 1990,
Journal of toxicology and environmental health,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
January 1989,
Journal of toxicology and environmental health,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
January 1987,
Drug metabolism and disposition: the biological fate of chemicals,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
August 1989,
Toxicology and applied pharmacology,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
December 1983,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M P Serve, and
D D Bombick, and
T M Baughman, and
B M Jarnot, and
M Ketcha, and
D R Mattie
February 1996,
Drug metabolism and disposition: the biological fate of chemicals,
