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The cytotoxic and mutagenic effects of 4-hydroxyaminobiphenyl (N-OH-ABP) were studied using Escherichia coli strains with different repair capacities. N-OH-ABP was equally cytotoxic for uvrA and recA mutants as well as in wild-type cells while polA mutant strains proved particularly sensitive to its toxicity. In contrast, the mutation frequency in the uvrA strains tested was elevated to 30-400-fold the wild-type values. We suggest that aminobiphenyl-DNA adducts responsible for mutation are repaired by UVR endonuclease but different pathways exist for removal of DNA lesions responsible for bacterial killing. From the 32P-postlabeling analysis, it was concluded that ABP-DNA adducts can be relatively rapidly repaired in wild-type strains, while persisting in the uvrA strains.
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
September 1986,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
September 1993,
Canadian journal of microbiology,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
January 1986,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
March 1974,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
October 1979,
Gan,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
October 1986,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
January 1975,
Basic life sciences,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
November 1978,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
April 1982,
Mutation research,
M Suzuki, and
K Takahashi, and
T Morita, and
M Kojima, and
M Tada
March 2010,
Mutagenesis,
