-transparent.png){kind=logo}
The mitochrondrial benzodiazepine receptor (mBzR) binds a subset of benzodiazepines and isoquinoline carboxamides with nanomolar affinity and consists of the voltage-dependent anion channel, the adenine nucleotide translocator, and an 18-kDa protein. The effect of ligands of the mBzR on two inner mitochondrial membrane channel activities was determined with patch-clamp techniques. The relative inhibitory potencies of the drugs resemble their binding affinities for the mBzR. Ro5-4864 and protoporphyrin IX inhibit activity of the multiple conductance channel (MCC) and the mitochondrial centum-picosiemen (mCtS) channel activities at nanomolar concentrations. PK11195 inhibits mCtS activity at similar levels. Higher concentrations of protoporphyrin IX induce MCC but possibly not mCtS activity. Clonazepam, which has low affinity for mBzR, is at least 500 times less potent at both channel activities. Ro15-1788, which also has a low mBzR affinity, inhibits MCC at very high concentrations (16 microM). The findings indicate an association of these two channel activities with the proteins forming the mBzR complex and are consistent with an interaction of inner and outer membrane channels.
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 1983,
Advances in biochemical psychopharmacology,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
November 1993,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 2011,
The Journal of biological chemistry,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
December 1989,
FEBS letters,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
May 2009,
Biochimica et biophysica acta,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 1987,
Physiology & behavior,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 2021,
Methods in molecular biology (Clifton, N.J.),
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 2020,
Frontiers in cell and developmental biology,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
January 1996,
Society of General Physiologists series,
K W Kinnally, and
D B Zorov, and
Y N Antonenko, and
S H Snyder, and
M W McEnery, and
H Tedeschi
July 1991,
FEBS letters,
