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Dimethylsulfoxide (DMSO) and WR-1065 are radioprotectors, in that they reduce the effectiveness with which ionizing radiation causes genetic damage. Unlike their protective effects with radiation, these agents potentiate the induction of micronuclei by bleomycin in the cytokinesis-block assay in G0 human lymphocytes. High concentrations of DMSO (1 M) are required to cause potentiation. In contrast, WR-1065 causes dose-dependent potentiation at relatively low concentrations (1.25 to 10 mM). Cytogenetic analysis supports the results from the micronucleus assay, showing higher levels of genetic damage induced by the combination of bleomycin with DMSO or WR-1065 than by bleomycin alone. Possible mechanisms of potentiation are proposed.
G R Hoffmann, and
S P Colyer, and
L G Littlefield
May 1994,
Mutation research,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
January 2001,
Environmental and molecular mutagenesis,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
May 1988,
Mutation research,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
January 1999,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
January 1995,
Environmental and molecular mutagenesis,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
October 1987,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
July 1995,
Toxicology letters,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
December 1994,
Mutation research,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
January 1995,
Environmental and molecular mutagenesis,
G R Hoffmann, and
S P Colyer, and
L G Littlefield
May 1998,
Mutagenesis,
