-transparent.png){kind=logo}
Okadaic acid, a protein phosphatase inhibitor, is a strong tumor promoter which apparently activates protein phosphorylation. To examine the role of protein phosphatases in stem cell growth and differentiation, embryonal carcinoma F9 cells were treated with okadaic acid. In the presence of this agent, the cells showed rapid morphological changes and arrest of proliferation at the M phase of the cell cycle, accompanied by a marked increase in the mRNA expression of various differentiation markers. Okadaic acid induced rapid increase in the mRNA levels of both c-jun and junB and results indicate that the inhibition of phosphatase by okadaic acid induces apparent activation of protein phosphorylation and may cause the expression of differentiation marker genes in F9 cells via the activation of AP-1.
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
April 1981,
Experimental cell research,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
June 1994,
FEBS letters,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
December 1984,
Cell differentiation,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
January 1991,
Experimental cell research,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
October 1994,
Experimental cell research,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
February 1987,
Experimental cell research,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
April 1987,
Biochemical pharmacology,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
September 1985,
European journal of cell biology,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
November 1989,
Genes & development,
Y Nishina, and
T Sumi, and
S A Iwai, and
Y Nishimune
November 1995,
Research communications in molecular pathology and pharmacology,
