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The glycolytic enzyme hexokinase plays a key role in regulating cell energy metabolism. Its activity has been associated with cell growth rate and, notably, with neoplastic transformation. NIH-3T3 cells were transfected with a tumor hexokinase cDNA. The transfected cells showed increased hexokinase amount and activity, mainly located in the particulate cellular fraction, increased glycolytic rate evaluated as lactate production, and, finally, enhanced growth rate. These data may suggest that high hexokinase activity might be not merely the consequence of peculiar metabolic demands by actively replicating normal or cancer cells, but also a modification able per se to drive, at least partially, a more intense mitotic activity.
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
January 1989,
Cellular signalling,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
June 1988,
Cancer research,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
June 1985,
Proceedings of the National Academy of Sciences of the United States of America,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
September 1987,
Proceedings of the National Academy of Sciences of the United States of America,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
June 1988,
The Journal of cell biology,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
January 1988,
Proceedings of the National Academy of Sciences of the United States of America,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
January 1990,
Proceedings of the Western Pharmacology Society,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
April 1989,
The American journal of physiology,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
October 1992,
Experimental cell research,
M Fanciulli, and
M G Paggi, and
T Bruno, and
C Del Carlo, and
F Bonetto, and
F P Gentile, and
A Floridi
November 1993,
The Journal of pharmacology and experimental therapeutics,
