[Spontaneous intracranial hemorrhage in term neonates and infants]. 1993

M Nagulić
Division of Paediatric Neurosurgery, University Clinical Centre, Belgrade.

Twenty nine full term haemophiliac neonates and babies, aged eight months with acute intracerebral haemorrhage are reported: four babies with haemophiliac status, one with intracerebellar bleeding due to microvascular malformation, and 24 babies in whom the cause of bleeding could not be established (probably vitamin-K deficiency). Fourteen surgeries were performed in ten babies. When dramatic neurological signs of spontaneous cerebral stroke develop in a term newborn or a baby they require immediate ultrasonographic examination. This noninvasive method can be repeated without risk to disclose all changes into the bleeding focus before and after surgical treatment. Selective cerebral angiography was exceptionally recommended for detection of suspected vascular malformation. Lumbar puncture was performed in more than one third of patients to confirm subarachnoid bleeding. However, this method has not been accepted being the purposeless and risky. Pharmacotherapy should be quickly used to correct the supposed vitamin-K deficiency and for replacement of relevant missing plasma factor of the prothrombin complex. To stop bleeding and to secure surgery the replacement substitute must raise the factors' level at least by 50 percent. The treatment of choice is vitamin-K1, 1-3 mg and fresh frozen plasma 10ml/kg of body weight. The neurological recovery was in general satisfactory after the stabilization of acute clotting disorder was achieved. Eight babies died (28 percent), five of them were admitted in deep comatose state.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D002543 Cerebral Hemorrhage Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA. Brain Hemorrhage, Cerebral,Cerebral Parenchymal Hemorrhage,Hemorrhage, Cerebral,Intracerebral Hemorrhage,Hemorrhage, Cerebrum,Brain Hemorrhages, Cerebral,Cerebral Brain Hemorrhage,Cerebral Brain Hemorrhages,Cerebral Hemorrhages,Cerebral Parenchymal Hemorrhages,Cerebrum Hemorrhage,Cerebrum Hemorrhages,Hemorrhage, Cerebral Brain,Hemorrhage, Cerebral Parenchymal,Hemorrhage, Intracerebral,Hemorrhages, Cerebral,Hemorrhages, Cerebral Brain,Hemorrhages, Cerebral Parenchymal,Hemorrhages, Cerebrum,Hemorrhages, Intracerebral,Intracerebral Hemorrhages,Parenchymal Hemorrhage, Cerebral,Parenchymal Hemorrhages, Cerebral
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

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