Recovery of forward-masked responses in ventral cochlear nucleus neurons. 1995

S E Shore
Department of Otolaryngology, Medical College of Ohio, Toledo, USA.

Single unit responses were obtained from 8 classes of cells in the ventral cochlear nucleus: Primarylike, Primarylike with characteristic frequencies below 1 kHz, Primarylike-Notch, Sustained Chopper, Transient-Chopper, Low-intensity Chopper; Onset with later activity and On-Chopper. Stimuli were paired tonebursts, a masker preceding a probe, separated by time delta t ms. The decrement in discharge rate to the probe was measured as a function of delta t and constituted the forward-masking recovery function. The recovery functions of primarylike units were similar to those reported for auditory nerve fibers, but recovered more slowly than all other classes of units in the ventral cochlear nucleus. Some units, such as onset units, were completely masked at short masker-probe intervals, while others, such as the low-intensity choppers, were less affected by the masker. More masking occurred in the first 2 ms of the response (onset rate) than in the overall response (average rate). Using shorter maskers and measuring the onset rate produced greater differences in masking functions between unit classes. Units with high spontaneous activity were more resistant to the effects of the masker than units with low and medium spontaneous activity. This was especially evident at high masker levels and short masker-probe intervals. Units other than primarylike often showed non-monotonic relationships between the firing rate evoked by the masker and the firing rate decrement in response to the probe, suggesting that both adaptation and inhibition are operating to produce the observed effects.

UI MeSH Term Description Entries
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010470 Perceptual Masking The interference of one perceptual stimulus with another causing a decrease or lessening in perceptual effectiveness. Masking, Perceptual,Maskings, Perceptual,Perceptual Maskings
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013017 Sound Localization Ability to determine the specific location of a sound source. Auditory Localization,Auditory Localizations,Localization, Auditory,Localization, Sound,Localizations, Auditory,Localizations, Sound,Sound Localizations
D017626 Cochlear Nucleus The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex. Cochlear Nuclei,Nuclei, Cochlear,Nucleus, Cochlear
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