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In a random series of 139 insulin-dependent diabetics aged 30 or under at the onset of disease islet-cell antibody (ICA) was detected in 33 cases (24%). In 27 patients who had had diabetes for less than one year 16 (59%) had ICA. Only one out of 51 patients with maturity onset diabetes who were not dependent on insulin were positive for ICA. Four out of 19 patients with late onset insulin-dependent diabetes had ICA. There was no association between the presence of ICA and any particular HLA phenotype. Within families containing two or more HLA haploidentical siblings with juvenile onset diabetes ICA was a variable finding both in its occurrence and in its relation to the duration of disease. A possible mode of action for the HLA-linked gene may be to permit a rapid immunological destructive process, possibly associated with viral infection.
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
January 1978,
Diabetes,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
May 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
March 1991,
JPMA. The Journal of the Pakistan Medical Association,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
September 1976,
Lancet (London, England),
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
July 1984,
Diabetologia,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
September 1976,
Diabete & metabolisme,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
November 1981,
Human immunology,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
November 1977,
American journal of diseases of children (1960),
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
March 1980,
Medicina clinica,
R Lendrum, and
G Walker, and
A G Cudworth, and
J C Woodrow, and
D R Gamble
August 1978,
The New England journal of medicine,
