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Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. 1995
K Yamada, and
K Kono, and
H Umegaki, and
K Yamada, and
A Iguchi, and
T Fukatsu, and
N Nakashima, and
H Nishiwaki, and
Y Shimada, and
Y Sugita
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset < 65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.
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