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Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease. 1998
H Hampel, and
T Sunderland, and
H U Kötter, and
C Schneider, and
S J Teipel, and
F Padberg, and
R Dukoff, and
J Levy, and
H J Möller
Department of Psychiatry, Ludwig-Maximilian University Munich, School of Medicine, Germany. hampel@psy.med.uni.muenchen.de
The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology.
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