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1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d. 2. In all cases 3,4,3-LIHOPO was appreciably more effective than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration. 3. Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body content of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The corresponding values using repeated DTPA administration were 80% and 54%. 4. It is concluded that 3,4,3-LIHOPO represents, potentially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contaminated by 228Th.
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
January 2003,
Radiation protection dosimetry,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
January 2000,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
December 1995,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
July 1996,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
June 1993,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
March 2012,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
June 1977,
Health physics,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
October 1995,
International journal of radiation biology,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
April 1986,
Health physics,
G N Stradling, and
S A Gray, and
M J Pearce, and
I Wilson, and
J C Moody, and
R Burgada, and
P W Durbin, and
K N Raymond
October 1993,
International journal of radiation biology,
